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. 2019 Oct 18;9:14962. doi: 10.1038/s41598-019-51488-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genus level analysis of the gut microbiota in Cln3^−/− and wild type mice kept on non-acidified water or receiving acidified water from postnatal day 21. Cln3^−/− and wild type (WT) male mice either were kept on non-acidified water or received acidified water from postnatal day 21 (weaning). Fecal pellets were collected at three and six months of age to analyze the gut microbiota by 16S rRNA gene sequencing. (a,b) The gut microbiota of Cln3^−/− and wild type mice at the genus taxonomic level are markedly different at both three (a) and six months (b) of age, and acidified water differentially changes the genus composition in Cln3^−/− and wild type mice. Columns and bars represent mean ± SEM and the symbols show the individual data (n = 5 mice). Statistical significance was determined by 2-way ANOVA with Bonferroni’s post-test for multiple comparisons (^#p < 0.0001, ^&p < 0.001, ^{^}p < 0.01, *p < 0.05; blue lines and symbols: WT vs. Cln3^−/− on Non-acidified; red lines and symbols: WT vs. Cln3^−/− on Acidified; dark red lines and symbols: WT on Non-acidified vs. WT on Acidified; black lines and symbols: Cln3^−/− on Non-acidified vs. Cln3^−/− on Acidified). Ph1, ; Ph2, Tenericutes; C1, Erysipelotrichia; C2, Verrucomicrobiae; C3, Mollicutes; O1, Erysipelotrichales; O2, Verrucomicrobiales; O3, Anaeroplasmatales.