Fig. 3.

Target genes and variant enhancer of SPATS2L locus. a SPATS2L locus showing TAD, variant region, (sub)threshold variants, CM PCHi-C, and RNA-seq. b Zoom of part of the variant region, showing PCHi-C and epigenetic datasets EMERGE and LA ATAC-seq. rs281766 is highlighted in yellow. c Information of variant rs281766, d TBX5 recognition motif and minor and major alleles of variant rs281766. e Table showing PCHi-C interaction with variant regions, expression per gene and final scores for the analyzed genes. TAD Topologically Associated Domain, CM cardiomyocyte, PCHi-C promoter capture Hi-C