Fig. 6.

Identification of cardiac regulatory elements and functional AF-associated non-coding variants. a ATAC-seq motif enrichment, b Area under the receiver operating characteristic curves showing the improved prediction of the revised EMERGE, c Browser view of human heart enhancer prediction for brain, previous heart prediction³⁸ and current heart prediction. hs1658 drives LacZ expression in the heart in the mouse embryo (Vista enhancer browser). d HOMER motif analysis on peak-calling ATAC-seq, EMERGE and overlapping peaks. e ATAC-seq and EMERGE peaks overlapping known AF GWAS variants, as well as variants that lie in promoters (red). f Allele-specific luciferase assay performed in iAM-1 cells. Error bars represent SD, *p < 0.05, **p < 0.01, and ***p < 0.001 (two-tailed Student’s t-test). Source data are provided as Source Data file. g SYNPO2L locus with GWAS variants, PCHi-C, ATAC-seq and EMERGE tracks. PCHi-C promoter capture Hi-C, ATAC-seq assay for transposase-accessible chromatin sequencing