Table 1. Summary of Significantly Associated Regions.

Endophenotype	Chromosome	Positiona	Lead SNP in Region	Effect Size (95% CI)b	P Value for Meta-analysisc	P Value for EAc	Nearest Gene	Genes Within 100 kb
Face memory	3p21	44813350 to 44874489	rs73076581	−0.72 (−1.00 to −0.45)	4.2 × 10−8	4.2 × 10−8	KIF15	ZNF502, ZNF501, TMEM42, TGM4
Continuous Performance Test	5p15	17439886 to 17443654	rs7706512	0.21 (0.14 to 0.28)	2.5 × 10−8	1.2 × 10−6	BASP1	None
Spatial memory	5p12	44791335 to 45215941	rs187763903	−0.72 (−0.98 to −0.47)	8.3 × 10−8	6.8 × 10−6	HCN1	None
Sensorimotor dexterity	9q21	72488418	rs140830767	−1.11 (−1.58 to −0.64)	4.0 × 10−8	3.3 × 10−6	C9orf135	None
Antisaccade task	9q31	107334694 to 107499546	rs77038697	−0.24 (−0.31 to −0.16)	3.5 × 10−8	3.5 × 10−8	OR13C9	OR13C4, OR13C3, OR13C8, OR13C5, OR13C2, OR13D1, NIPSP3A
Abstraction and mental flexibility	10q23	85685084 to 85719133	rs11200733	−0.56 (−0.20 to −0.07)	1.5 × 10−8	6.1 × 10−8	NRG3	None
Antisaccade task	12p13	9082391 to 9135281	rs117302528	−0.20 (−0.28 to −0.13)	5.4 × 10−8	3.7 × 10−7	PHC1	A2ML1, M6PR, KLRG1
Spatial processing	14q11	23364106 to 23473706	rs45543740	−0.62 (−0.82 to −0.41)	1.7 × 10−8	5.8 × 10−8	AJUBA	REM2, RBM23, PRMT5, HAUS4, PSMB5, PSMB11, ACIN1
Spatial processing	19q12	44813350 to 44874489	rs4805491	−0.46 (−0.61 to −0.31)	3.8 × 10−8	6.0 × 10−7	CCNE1	URI1

Abbreviations: EA, European ancestry; SNP, single-nucleotide polymorphism.

^aIndicates hg19 region spanned by SNPs tagged by the lead SNP. The boundaries of each gene are expanded by 20 kb on each side to capture putative regulatory elements.

^bCalculated from the lead SNP from the meta-analysis and the corresponding lower and upper bounds, respectively, of the 95% CI.

^cIndicates P value of lead SNP.