Table 2. Change in Outcomes Over Timea.
| Variable | 6 mo | 1 y | 2 y | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No Surgery (n = 1879) | Parathyroidectomy (n = 501) | Difference in Change (95% CI) | P Value | No Surgery (n = 1879) | Parathyroidectomy (n = 501) | Difference in Change (95% CI) | P Value | No Surgery (n = 1879) | Parathyroidectomy (n = 501) | Difference in Change (95% CI) | P Value | |
| Median MAP (SD), mm Hg | 92.4 (8.9) | 93.3 (8.7) | NA | NA | 92.7 (8.8) | 93.1 (9.1) | NA | NA | 92.5 (8.6) | 93.5 (9.1) | NA | NA |
| No. of antihypertensive medications, mean (SD) | 1.5 (1.2) | 1.2 (1.1) | NA | NA | 1.5 (1.3) | 1.1 (1.1) | NA | NA | 1.3 (1.3) | 1.0 (1.1) | NA | NA |
| Change in Outcome Compared With Baseline | ||||||||||||
| Median MAP (SD), mm Hg | −0.2 (8.5) | −1.0 (7.6) | 0.8 (0.0 to 1.6) |
.046 | 0.1 (8.7) | −1.2 (7.7) | 1.3 (0.5 to 2.2) |
.002 | −0.1 (8.7) | −0.8 (7.9) | 0.7 (0.0 to 1.8) |
.04 |
| No. of antihypertensive medications, mean (SD) | 0.0 (0.7) | −0.1 (0.6) | 0.1 (0.0 to 0.1) |
.01 | −0.0 (0.8) | −0.1 (0.7) | 0.1 (0.0 to 0.2) |
.007 | −0.3 (1.1) | −0.3 (0.9) | 0.1 (−0.1 to 0.1) |
.09 |
| No./Total No. (%) of Patients Compared With Baseline | ||||||||||||
| Prescribed more antihypertensive medications | 298 (15.9) | 49 (9.8) | NA | .001 | 340 (18.1) | 54 (10.8) | NA | <.001 | 330 (17.6) | 61 (12.2) | NA | .004 |
| No change in No. of antihypertensive medications | 1313 (69.9) | 377 (75.2) | NA | .02 | 1208 (64.3) | 342 (68.3) | NA | .10 | 986 (52.5) | 279 (55.7) | NA | .20 |
| Prescribed fewer antihypertensive medicationsb | 268/1432 (18.7) | 75/374 (20.1) | NA | .56 | 331/1432 (23.1) | 105/374 (28.1) | NA | .05 | 563/1432 (39.3) | 161/374 (43.0) | NA | .19 |
| Stopped taking antihypertensive medicationsb | 102/1432 (7.1) | 34/374 (9.1) | NA | .20 | 166/1432 (11.6) | 58/374 (15.5) | NA | .04 | 397/1432 (27.7) | 117/374 (31.3) | NA | .17 |
| Started taking antihypertensive medicationsc | 120/447 (26.8) | 12/127 (9.4) | NA | <.001 | 136/447 (30.4) | 13/127 (10.2) | NA | <.001 | 124/447 (27.7) | 18/127 (14.2) | NA | .002 |
Abbreviations: MAP, mean arterial pressure; NA, not applicable.
a
Difference in change is between the parathyroidectomy group and the nonsurgical group compared with baseline.
b
Variable includes only patients taking antihypertensive medications at baseline (1432 in the nonsurgical group and 374 in the parathyroidectomy group).
c
Variable includes only patients taking no antihypertensive medications at baseline (447 in the nonsurgical group and 127 in the parathyroidectomy group).