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. Author manuscript; available in PMC: 2020 Jan 3.
Published in final edited form as: Nat Med. 2019 Jul 3;25(7):1123–1130. doi: 10.1038/s41591-019-0500-9

Extended Data Fig. 6.

Extended Data Fig. 6

ABR amplitude, latencies and correlation of thresholds with surviving hair cells. (a) Peak 1 amplitudes and Peak 1 latencies (b) measured from 8 kHz ABR waveforms at the 8 week time point, from examples shown in Figs. 5a & 5c, for all Tmc1Bth/WT mice injected with AAV-SaCas9-KKH-gRNA-4.2 (green traces), and an example of an uninjected Tmc1Bth/WT (red trace). (c) Mean ABR thresholds measured at 24 weeks, evoked by 8 and 16 kHz tone bursts (from Extended Data Fig. 5e) plotted as function of the mean percentage of surviving inner and outer hair cells from the 8 and 16 kHz regions (from Fig. 3h). The data were fit with a linear equation that had a slope of −2.1 dB/% and a correlation coefficient of −0.82 (red line, Pearson’s r).