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. 2019 Oct 21;12:99. doi: 10.1186/s13048-019-0573-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — JNK signaling pathway mediated drug resistance. a NK signaling pathway mediated by the JNK signaling pathway in ovarian cancer can repair DNA damage through SIRT6/PARP1 or reduce the sensitivity of ovarian cancer tissues to chemotherapy by c-Jun. b Drug resistance mediated by JNK signaling pathway also involves microRNA. MiR-21 inhibits the expression of PDCD4 and promotes resistance, or the interaction between miR-134 and JNK signaling pathway promotes the activation of c-jun/ATF2 and promotes drug resistance