Table 6.

The generation-dependent sexual difference in the prevalence of atopic asthma and extrinsic atopic dermatitis (AD).

	Child			Adolescent–Adult
Atopic Asthma	Atopic Diathesis		Th2 Regulation by DHEA	Th2 Regulation by Sex Hormones	Th2 Regulation by DHEA
M	+~++		↓	↓↓by A	↓
F	+		↓↓	↑↑↑↑by E, P	↓↓
Prevalence	M > F			M ≪ F
Extrinsic AD	Atopic Diathesis	Filaggrin Gene Nutation	Th2 Regulation by DHEA	Th2 Regulation by Sex Hormones	Th2 Regulation by DHEA	Skin Barrier Impairment by Sex Hormones
M	+~++	+ or −	↓	↓↓by A	↓	↑by A
F	+	+ or −	↓↓	↑↑↑↑by E, P	↓↓	↓↓by E ↑by P Totally↓
Prevalence	M > F			M < F

↑, Stimulation; ↓, Suppression; Th2, T helper 2 cell; DHEA, dehydroepiandrosterone; F, female; M, male; A, androgen; E, estrogen; P, progesterone.