Evidence for efficacy in males 9 to 26 years
STUDY DETAILS					SUMMARY
Study	Vaccine	Study Design	Participants	Summary of Key Findings	Level of Evidence	Quality
Guiliano et al. (88)	Gardasil®	Randomized, double-blind, placebo-controlled Three doses at 0, 2 and 6 months 36 month follow-up (30.1 month mean for these results) Protocol 020	n=4065 males Heterosexual males 16 to 23 years (n=3463); MSM 16 to 26 years (n=602)	EGL (external genital lesion) efficacy 90.4% (95% CI: 69.2-97.9) Type-specific EGL efficacy: Types 6, 11, 16, and 18: 84.3% (95% CI: 46.5-97.0), 90.9% (95% CI: 37.7-99.8), 100% (95% CI: 0-100), 100% (95% CI: <0-100) Efficacy against condyloma and PPPIN (penile/perianal/perineal intraepithelial neoplasia) 89.4% (95% CI: 65.5-97.9)	Level I	Good
Palefsky et al. (153)	Gardasil®			Efficacy against persistent infection: 85.6% (95% CI: 75.1-92.2) Efficacy against persistent infection from individual HPV types 6, 11, 16 and 18 88.0% (95% CI: 66.3-96.9), 93.4% (95% CI: 56.8-99.8), 78.7% (95% CI: 55.5-90.9), 96.0% (95% CI: 75.6-99.9) respectively. Efficacy against infection at ≥1 visit: 44.7% (95% CI: 31.5-55.6)	Level I	Assessment pending peer-reviewed publication