Figure 4.

Knockdown of PVT1 negatively modulates Wnt/β-catenin signaling in pituitary adenoma tissues and cells. (A, B) β-catenin, cyclin D1, and c-Myc expressions were evaluated using Western blot analysis in pituitary adenoma tissues or cells and normal tissues or cells. (C) The protein levels of β-catenin, c-Myc, and cyclin D1 were examined in PVT1-downregulated pituitary adenoma cell lines. Means ±SDs of results obtained from at least 3 experiments are shown. ** p<0.05 vs. Normal control (NC) group, Normal tissues, or NHPG cells.