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. 2019 Oct 14;13:1054. doi: 10.3389/fnins.2019.01054

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Copyright © 2019 Pathak, Srivastava, Padma, Gulati and Rajeswari.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Validation results of four differentially expressed PBMC proteins in FRDA using qPCR. Box-and-whiskers plots of mRNA levels of (A) actin alpha cardiac muscle (ACTC1), (B) caspase 8 (Cas8), (C) serotransferrin (TF), and (D) pyruvate dehydrogenase subunit E1 (PDHE1) in PBMC of FRDA patients and controls. The ends of the whiskers show the position of the lowest and highest quartiles of the data while the edges and line in the center of the box show the upper and lower quartiles. Line inside the box represents the median value (p < 0.001) obtained using Mann–Whitney U test.