TABLE 4.
Differentially expressed PBMC proteins in Friedreich’s ataxia patients and their characterization using Mascot search and the proteins identified are given in the last column.
| Spot no. | Fold change | P-value | pI | Mol wt (kDa) | MASCOT score | Accession no. | Coverage % | Matched peptide | Protein identified |
| Up-regulated proteins | |||||||||
| 298 | 1.90 | 0.048 | 5.8 | 90 | 78 | TF_HUMAN | 38 | 8 | Serotransferrin precursor |
| 724 | 4.17 | 0.028 | 4.2 | 92 | 63 | SORB1_HUMAN | 8 | 17 | Sorbin and SH3 domain containing 1, isoform CRA |
| 689 | 2.76 | 0.046 | 4.7 | 46 | 88 | CASP-8_HUMAN | 26 | 16 | Caspase 8 |
| 834 | 2.61 | 0.049 | 4.6 | 58.9 | 53 | NAA16_HUMAN | 7 | 18 | N-alpha-acetyltransferase 16 |
| Down-regulated proteins | |||||||||
| 523 | –2.61 | 0.043 | 5.9 | 35.8 | 138 | PDHE1B_HUMAN | 32 | 14 | Pyruvate dehydrogenase E1 component subunit β |
| 158 | –3.41 | 0.0026 | 4.1 | 70 | 43 | HNRNPUL2_HUMAN | 12 | 26 | Alternate protein HNRNPUL2 |
| 451 | –1.52 | 0.0056 | 5.8 | 20.3 | 81 | MYL12A_HUMAN | 9 | 12 | Myosin regulatory light chain 12A |
| 698 | –4.92 | 0.038 | 4.3 | 31 | 101 | ACTC1_HUMAN | 22 | 12 | Actin alpha cardiac muscle 1 |