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. 2019 Sep 3;294(42):15206–15217. doi: 10.1074/jbc.RA119.010328

Figure 2.

Figure 2.

The sucrose-induced, circadian rhythm–dependent amplification of lipogenesis was confirmed to be fructose-dependent. a, liver weights in rats after being fed an experimental diet for 4 weeks, which contained or lacked fructose (p < 0.001; n = 12/group). b–d, hepatic total lipids (p < 0.001), triglyceride levels (p < 0.001), and cholesterol levels (p < 0.001) after a 4-week treatment (n = 12/group). e and f, serum triglyceride and cholesterol concentrations at ZT2 and ZT14 after a 4-week treatment (n = 6/group at either time point). g–l, the mRNA levels of several fatty acid synthesis genes and clock genes at ZT2 and ZT14 (n = 6/group at either time point). One-way ANOVA followed by Duncan's multiple-range test was performed among five groups. Two-way ANOVA was performed to determine the interaction effect of time and diet. When a significant interaction effect was observed, Duncan's multiple-range post hoc test was performed for either time point. Different letters over bars indicate significant differences, as determined by Duncan's multiple-range test. Error bars, S.D.