Table 2.

Identification of HC2 cleavage mediated by ADAMTS-5 or MMPs in patients with arthritis

Arthropathy	No. of patients	No. of patients with ADAMTS-5 product	No. of patients with MMP-3/-7 product	Male/female	Age (average)	BMIa (average)
Osteoarthritis	10	9	0	5/5	25–79 (55.8)	15.8–33.6 (26.8)
Rheumatoid arthritis	9	8	2	2/7	31–79 (53.6)	18.4–33.8 (23.6)
Spondyloarthropathy	14	12	1	7/7	21–77 (46.8)	21.6–38.1 (26.9)
Total	33	29	3	14/19	21–79 (51.1)	18.4–38.1 (25.9)

^a Information not available for all patients (OA, 8 of 10; RA, 8 of 9; SpA, 10 of 14).