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. 2019 Oct 17;12:2145–2155. doi: 10.2147/DMSO.S223842

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© 2019 Sun et al.

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JMT regulated NLRP3 inflammasome expression in SNs of diabetic rats.

Notes: Representative staining of NLRP3 (magnification, ×400) (A–D). Brown color corresponds to protein of interest, and blue color corresponds to nuclear staining. Normal control (A), Diabetes (B), Diabetes + JMT (C), Diabetes + ALA (D). Representative Western blot images of NLRP3, pro-caspase-1, and cleaved-caspase-1 (E). Quantitative analysis of positive-stained areas relative to total tissue areas (F). Densitometric analysis of NLRP3, pro-caspase-1, and cleaved-caspase-1 protein expression normalized to β-actin (G–I). Data are the mean ± SEM from three independent experiments. ***P < 0.001 vs normal group, ^##P < 0.01 vs diabetes group, ^###P < 0.001 vs diabetes group.

Abbreviations: JMT, Jinmaitong; NLRP3, NACHT, LRR and PYD domains-containing protein 3; SN, sciatic nerve; ALA, alpha-lipoic acid; SEM, standard error of mean.