Table 3.

Correlation Between Hematological Parameters And Clinical Features Of 138 Patients With SCLC By Chi-Square Test

Clinical Features		NLR0			PLR0			LMR0			SII0			MPV0			PLT0/MPV0 Ratio
≤2.1	>2.1	P-Value	≤190	>190	P-Value	≤3.1	>3.1	P-Value	≤465	>465	P-value	≤10.0	>10.0	P-value	≤21.0	>21.0	P-value
Gender	Female	11	19	0.525	18	12	0.065	12	18	0.156	10	20	0.851	16	14	0.815	13	17	0.773
	Male	33	75		83	25		59	49		38	70		55	53		50	58
Age (year)	<65	24	61	0.244	59	26	0.205	45	40	0.657	28	57	0.565	47	38	0.252	38	47	0.777
	≥65	20	33		42	11		26	27		20	33		24	29		25	28
Stage	Limited stage	10	24	0.722	30	4	0.023	16	18	0.555	13	21	0.626	20	14	0.322	13	21	0.317
	Extensive stage	34	70		71	33		55	49		35	69		51	53		50	54
Extensive stage	Single organ metastasis	51	26	<0.001	55	22	0.792	57	20	0.149	45	32	0.112	51	26	0.184	56	21	0.099
	Multiple organ metastasis	7	20		20	7		16	11		11	16		14	13		15	12
Chemotherapeutic regimen	Etoposide + Cisplatin or Carboplatin	18	37	0.863	38	17	0.376	25	30	0.251	20	35	0.751	28	27	0.918	26	29	0.756
	Etoposide + Luoplatinum	26	57		63	20		46	37		28	55		43	40		37	46
Radiotherapy	Yes	21	37	0.353	49	9	0.011	26	32	0.185	24	34	0.166	29	29	0.772	24	34	0.391
	No	23	57		52	28		45	35		24	56		42	38		39	41
Results of the first evaluation	ORR (CR +PR)	33	56	0.078	72	17	0.006	41	48	0.088	36	53	0.060	40	49	0.039	50	39	<0.001
	SD+PD	11	38		29	20		30	19		12	37		31	18		13	36
PFS (months)	<7	17	60	0.005	47	30	<0.001	47	30	0.011	19	58	0.005	47	30	0.011	29	48	0.034
	≥7	27	34		54	7		24	37		29	32		24	37		34	27
Reasons for the progress	Lesions increase	24	52	0.932	54	22	0.531	41	35	0.516	20	56	0.021	43	33	0.182	33	43	0.560
	Distant metastasis	20	42		47	15		30	32		28	34		28	34		30	32
Grade 3–4 myelosuppression	Yes	17	40	0.663	40	17	0.503	32	25	0.355	25	32	0.060	28	29	0.646	29	28	0.301
	No	27	54		61	20		39	42		23	58		43	38		34	47

Abbreviations: ORR, objective response rate; CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; LMR, lymphocyte-to-monocyte ratio; SII, systemic inflammation index; MPV, mean platelet volume; PLT/MPV ratio, total platelet count/mean platelet volume.