Fig. 2. Inhibition of RIPK1 attenuated AP-related injury in rats.

a Representative immunoblot images and b quantitation of IL-1β, HMGB1, Caspase-1, ICAM-1, NF-κB p-p65/p65, IL-18, TNF-α, and AQP8 expression in pancreatic tissues harvested from the rats described above. β-Actin was used as the protein loading control. c Representative TEM images of pancreatic tissues from the rats described in Fig. 1a; bar: 2 μm. The data are the means ± S.Ds. (n = 3). *P < 0.05 versus sham, ^P < 0.05 versus AP