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. 2019 Aug 2;51(8):1–17. doi: 10.1038/s12276-019-0278-3

Fig. 8. A RIPK1/NF-κB p65/AQP8 axis might exist during AP in rats.

Fig. 8

a Representative images (4×) of hematoxylin and eosin-stained pancreatic tissues harvested from rats subjected to sham operation, AP, AP + Nec-1, AP + PDTC or AP + Nec-1 + PDTC for 24 h after AP induction. b Histopathological scoring was performed to evaluate pancreatic injury in the rats described above. c Representative immunoblot images and d quantitation of the p-RIPK1/RIPK1, NF-κB p-p65/p65, and AQP8 levels in pancreatic tissues harvested from the rats described in Fig. 8a. β-Actin was used as the protein loading control. e Relative mRNA expression of AQP8 in pancreatic tissues harvested from the rats described in Fig. 8a. f The levels of CRP, TNF-α, IL-18, IL-1β, and IL-6 in peripheral blood samples harvested from the rats described in Fig. 8a were spectrophotometrically measured. The data are the means ± S.Ds. (n = 3). *P < 0.05 versus sham, ^P < 0.05 versus AP