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. 2019 Sep 30;51(10):114. doi: 10.1038/s12276-019-0315-2

Fig. 5. DCA upregulates hepatic FGF21 expression, resulting in BAT activation.

Fig. 5

a, b Serum FGF21 concentration (a) and Fgf21 mRNA levels in the liver (b) of ApoE−/− mice (chow-fed group, n = 5–6; WD-fed group, n = 15–16). c Fgfr and Klb mRNA levels in BAT (chow-fed group, n = 5; WD-fed group, n = 15–16). d Serum ALT and AST concentrations (chow-fed group, n = 6; WD-fed group, n = 15–16). e, f FGF21 in the serum (e) and Fgf21 mRNA expression in the liver (f) after oral DCA (100 mg/kg) administration for 1 week (e, n = 8 per group; f, n = 4–5 per group). g Fgf21 mRNA expression level in mouse primary hepatocytes after DCA (1 mM) treatment for the indicated time. h Concentration of FGF21 secreted from mouse primary hepatocytes after DCA treatment for the indicated time at the indicated dose. The values are expressed as the mean ± SEM (a–f) or ± SD g–h. Statistical analysis was performed by Student’s t-test. *p < 0.05 vs. the chow-fed group or the DCA untreated group, †p < 0.05 vs. the WD-fed group, ‡p < 0.05 vs. the DCA (100 mg/kg)-treated group