Table 1.
Univariate and multivariate Cox regression analysis of disease-free survival in colorectal cancer (combined with CIT and AUS cohorts)
| Variable | Univariate | Multivariate | Multivariate (stepa) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| n | HR (95% CI) | P-value | n | HR (95% CI) | P-value | n | HR (95% CI) | P-value | |
| Gender (male vs. female) | 782 | 0.803 (0.617–1.047) | 0.105 | 721 | 0.78 (0.583–1.045) | 0.096 | 721 | 0.783 (0.587–1.045) | 0.097 |
| Age (<75 or ≥75) | 782 | 0.986 (0.736–1.321) | 0.927 | 1.203 (0.858–1.685) | 0.283 | ||||
| AJCC Stage (I, II, III, or IV) | 782 | 2.837 (2.334–3.447) | <0.001 | 2.267 (1.781–2.885) | <0.001 | 2.327 (1.877–2.886) | <0.001 | ||
| Location (distal, proximal, or rectum) | 782 | 0.765 (0.602–0.973) | 0.029 | 0.809 (0.622–1.053) | 0.114 | 0.823 (0.636–1.066) | 0.14 | ||
| Chemotherapy (No or Yes) | 766 | 1.841 (1.404–2.414) | <0.001 | 1.101 (0.789–1.536) | 0.572 | ||||
| CMS subtype (CMS1, 2, 3, or 4) | 736 | 1.274 (1.123–1.446) | <0.001 | 1.134 (0.992–1.296) | 0.066 | ||||
| PI (low-risk or high-riskb) | 782 | 1.984 (1.514–2.6) | <0.001 | 1.794 (1.327–2.426) | <0.001 | 1.812 (1.342–2.448) | <0.001 | ||
HR hazard ratio, CI confidence interval, CMS consensus molecular subtype, PI prognostic index
aA backward-forward step procedure was applied to optimize the multivariate model with the most informative variables
bPredicted outcome in Fig. 2b, c was used for analysis