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. 2019 Jul 10;51(7):1–14. doi: 10.1038/s12276-019-0272-9

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© The Author(s) 2019, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, b The effect of adenine treatment on BUN and serum creatinine concentrations. c Adenine and vitamin D treatment on serum calcium levels. d Histological von Kossa staining. e Quantification of calcification in the aortic valves. (Scale bar = 100 μm; n = 3 for each group; ^#p < 0.05, ^###p < 0.001 compared with control)