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. 2019 Jul 8;51(7):76. doi: 10.1038/s12276-019-0274-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a In vivo BLI and FMI of control and sorafenib and apatinib treatment groups at the time points of pretreatment and 0, 4, 8, 12, 24, and 48 h post-treatment of AngioSense 750 EX. b Ex vivo white light imaging, BLI, and FMI livers from mice and H&E staining of liver tumor specimens at 48 h post-treatment with AngioSense 750 EX. Black arrows indicate tumor tissues. c The 3D CTA in the control and sorafenib and apatinib treatment groups 15 min after Fenestra VC injection. The red dotted line denotes tumor blood vessel areas