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Complex and CuCl2 enhance p53 transcriptional functions.
Relative normalized expression levels of TP53 (A), MDM2 (B) and PUMA (C) genes in HCT116 and MCF7 cells after 24 h treatment with Ligand, Complex and CuCl2 at 50 µM. Data are expressed as mean ± S.D., n = 3; *p<0.05, **p<0.001. D – Complex is more potent than Ligand in luciferase-based p53 pathway activation assay. Although, CuCl2 demonstrates the most profound effect on p53 transcriptional activity (7-fold increase).
