Table 1. . Morphological properties of large cell neuroendocrine carcinoma, neuroendocrine negative small cell lung cancer and classical neuroendocrine positive small cell lung cancer.

Feature	LCNEC	SCLC NE-	SCLC NE+
Mostly smokers	Yes	Yes	Yes
Median age	∼67 years	∼65 years	∼65 years
Cell size	Typical of NSCLC	Larger than classical SCLC	Small
Cytoplasm	Abundant	More plentiful than classical SCLC	Scarce
Nucleoli	Prominent	Prominent	Not prominent
Mitotic rate	High	High	High
Nuclear chromatin	Less uniform	More uniform	More uniform
Cell borders	More distinct	Less distinct	Less distinct

LCNEC: Large cell neuroendocrine carcinoma; NE: Neuroendocrine; NSCLC: Non-small-cell lung carcinoma; SCLC: Small cell lung cancer.