Table 3. . Overall best response per RECIST V 1.1.

	Cohort A (metformin) N = 17†	Cohort B (no metformin) N = 26†
Best response – CR – PR – SD – PD	0 (0%) 7 (41.1%) 5 (29.4%) 5 (29.4%)	0 (0%) 8 (30.8%) 8 (30.8%) 10 (38.5%)	p = 0.7
ORR	41.1%	30.7%	p = 0.4
DCR	70.5%	61.6%	p = 0.5
Median time to achieve best response (months)	2.7	3.2

^†Radiographically evaluable patients. Three patients in cohort A and four patients in cohort B were not evaluable.

CR: Complete response; DCR: Disease control rate; ORR: Objective response rate; PD: Progressive disease; PR: Partial response; SD: Stable disease.