Table 4. . Overall best response per RECIST V 1.1 in patients who have received immune checkpoint inhibitor as second- or third-line therapy.

	Cohort A (metformin) N = 9†	Cohort B (no metformin) N = 15†
Best response – CR – PR – SD – PD	0 (0%) 4 (44.4%) 3 (33.3%) 2 (22.2%)	0 (0%) 1 (6.7%) 6 (40%) 8 (53.3%)	p = 0.1
ORR	44.4%	6.7%	p = 0.02
DCR	77.7%	46.7%	p = 0.1
Median time to achieve best response (months)	3	4.6

^†Radiographically evaluable patients. Two patients in cohort A and three patients in cohort B were not evaluable.

CR: Complete response; DCR: Disease control rate; ORR: Objective response rate; PD: Progressive disease; PR: Partial response; SD: Stable disease.