Figure 11.

Schematic models of Atoh1 and Ptf1a function and expression in the cerebellar neuroepithelium. Ai, Temporal schedule of the neurogenesis in the cerebellar primordium of wild-type mice drawn according to previous studies. Aii, Aiii, Summary for the birthdates of ectopically produced neurons in the knock-in mice or electroporated mice that ectopically express Atoh1 (Aii) and Ptf1a (Aiii). Red arrowheads indicate BrdU administration at E10.5 or E14.5 to the knock-in mice. Black arrowheads indicate electroporation with Atoh1 or Ptf1a at E12.5 to the wild-type VZ or RL, respectively. B, C, Schematic models for Ptf1a and Atoh1 expression in the cerebellar VZ of Ptf1a^Atoh1 heterozygotes and homozygotes. Left and right boxes represent cells in the VZ at indicated stages. WT, Wild-type; EP, electroporation; KI, knock-in.