Table 1.
A List of Published Peptides and Other Anti-Glypican 3-Targeting Moieties
| GPC3-targeting molecule | Humanized | KD (nM) | References |
|---|---|---|---|
| DHLASLWWGTEL (TJ12P1) | N/A | 390 (with Cy5.5) | 9 |
| RLNVGGTYFLTTRQ (L5) | N/A | 44.7 | 7,10 |
| DYEMHLWWGTEL (IPA) | N/A | 225.1 | 14 |
| THVSPNQGGLPS (GBP) | N/A | 753 | 15 |
| hGC33 | Yes | 0.67 | 16 |
| YP7 (hYP7) | Yes | 0.3a | 12 |
| HN3 | Yes | 0.6 | 8 |
| HS20 | Yes | 0.3 | 17 |
| αGPC3-F(ab′) | No | 0.03 | 13 |
a
KD value is for the nonhumanized version of the antibody, as no KD was reported for the humanized variant (hYP7).
GPC3, Glypican 3.
N/A, not applicable.