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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: J Allergy Clin Immunol. 2018 Nov 12;143(5):1865–1877.e4. doi: 10.1016/j.jaci.2018.08.053

FIG 5. CRF2−/− BMMCs exhibit exacerbated Ca2+ mobilization responses to diverse mast cell stimuli.

FIG 5.

Murine BMMCs from female mice were loaded with Fluo 4 Ca2+ indicator and stimulated with indicated MC degranulation stimuli as described in the Material and Methods Section. Intracellular Ca2+ mobilization (presented as ∆F480/F540 or as representative traces) in response to indicated concentrations of IgE/DNP (A,E), A23187 (B,F) and c48/80 (C,G) and Carbachol (D,H). Data shown are the means ± SE and are representative of 3 independent experiments performed in triplicate. Data were analyzed using a 1-way ANOVA *P < 0.05, **P < 0.001, ***P < 0.0001.