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. 2014 Feb 12;34(7):2514–2523. doi: 10.1523/JNEUROSCI.1407-13.2014

Figure 5.

Figure 5.

Inhibitors of COX-2, but not COX-1, selectively reverse LPS-induced decreases in object exploratory behavior. A–C, CRTH2+/+ mice were intraperitoneally injected with vehicle (Veh) or 10 mg/kg indomethacin (Indo; A; n = 6–7), 10 mg/kg SC-560 (B; n = 5–6), or 5 mg/kg NS-398 (C; n = 7–8), 1 h before intraperitoneal injection of 5 μg LPS (closed columns) or saline (open columns). Ten hours after LPS injection, object exploratory behavior was examined. D–F, One hour before intraperitoneal injection of 5 μg LPS (closed columns) or saline (open columns), CRTH2+/+ mice were intraperitoneally injected with Veh or NS-398, and their locomotor activity at 2 h (D), food intake for 24 h (E), and duration engaged in social interaction at 10 h (F) after LPS injection were measured in the same animals (n = 12). Data are expressed as the mean ± SEM; *p < 0.05, **p < 0.01 by two-way ANOVA followed by Tukey—Kramer test.