Table 1.

SHIRPA primary screening in CRTH2^+/+ and CRTH2^−/− mice

Paradigm	Examination	CRTH2+/+	CRTH2−/−	p value
Appearance	Body weight (g)	27.4 ± 0.7	26.4 ± 0.7	0.207
	Body position	3.67 ± 0.2	4.00 ± 0.0	0.083
	Respiration rate	1.92 ± 0.1	1.91 ± 0.1	0.950
	Heart rate	0.50 ± 0.2	0.45 ± 0.2	0.831
	Tremor	0.10 ± 0.1	0.00 ± 0.0	0.338
	Palpebral closure	0.00 ± 0.0	0.00 ± 0.0	N.D.
	Piloerection	0.00 ± 0.0	0.00 ± 0.0	N.D.
	Skin color	1.00 ± 0.0	1.00 ± 0.0	N.D.
	Lacrimation	0.10 ± 0.1	0.00 ± 0.0	0.361
	Salivation	0.67 ± 0.1	0.60 ± 0.2	0.827
Motor functions	Spontaneous activity	1.50 ± 0.3	2.00 ± 0.3	0.196
	Transfer arousal	2.50 ± 0.4	3.09 ± 0.3	0.205
	Gait	0.00 ± 0.2	0.00 ± 0.0	0.166
	Pelvic elevation	1.58 ± 0.2	1.91 ± 0.1	0.158
	Tail elevation	0.92 ± 0.2	0.82 ± 0.1	1.000
	Trunk curl	0.00 ± 0.0	0.00 ± 0.0	N.D.
	Limb grasping	0.00 ± 0.0	0.00 ± 0.0	N.D.
	Grip strength	2.33 ± 0.1	2.18 ± 0.2	0.555
	Righting reflex	0.00 ± 0.0	0.00 ± 0.0	N.D.
	Contact righting reflex	0.83 ± 0.1	0.91 ± 0.1	0.658
	Negative geotaxis	0.25 ± 0.1	0.10 ± 0.1	0.325
Sensory functions	Touch escape	2.25 ± 0.3	2.18 ± 0.2	0.642
	Positional passivity	0.33 ± 0.1	0.18 ± 0.1	0.419
	Visual placing	2.08 ± 0.1	1.82 ± 0.2	0.166
	Pinna reflex	0.42 ± 0.1	0.36 ± 0.2	0.799
	Corneal reflex	0.83 ± 0.1	1.00 ± 0.0	0.166
	Toe pinch	2.83 ± 0.1	2.73 ± 0.2	0.852
Anxiety level	Fear	0.00 ± 0.0	0.00 ± 0.0	N.D.
	Urination	0.29 ± 0.2	0.45 ± 0.2	0.643
	Defecation	5.17 ± 1.1	5.91 ± 0.9	0.709
	Vocalization	0.00 ± 0.0	0.10 ± 0.1	0.296
Aggression	Provoked biting	0.10 ± 0.1	0.27 ± 0.1	0.242

Data are expressed as the mean ± SEM (n = 11–12). p values were calculated using the Mann-Whitney U test. N.D., not detected.