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. 2019 Oct 10;10(1):459–468. doi: 10.1080/21655979.2019.1676485

Figure 5.

Figure 5.

SREBP1 regulates caspase-7 expression and colon cancer chemoresistance. a, Representative IHC staining for SREBP1 and caspase-7 in serial sections from colon cancer patient samples. The sample used was derived from colon cancer cases. Scale bars represent 50μm. b, Kaplan-Meier survival curves of overall survival duration based on SREBP1 expression in the CRC patient tissues. c, Kaplan-Meier survival curves of overall survival duration based oncaspase-7 expression in the CRC patient tissues.The receiver operatingcharacteristic curve was used to define the cutoff, and log-rank analysis was used to test for significance. d, SW480 cells were co-transfected into Lv- SREBP1 shRNA and caspase-7 siRNA for 24 h, then treated with 20 uM Gem for 72 h. Cell proliferation assay of SW480 cells using cell counting kit-8 assay. e, SW480 cells were co-transfected into Lv- SREBP1 shRNA and caspase-7 siRNA for 24 h, then treated with 20 uM Gem for 72 h. Cell apoptosis was analyzed on a FACSCalibur. Data are shown as mean±SD.