Table 2.

Adjunctive aripiprazole for antipsychotic-related hyperprolactinaemia: ADRs

Secondary outcome	Study	Control group		Aripiprazole group		Findings
		Total (n)	Events (n)	Total (n)	Events (n)
Prolactin-related symptom*	Zhou et al 201424	50	28	50	4	p<0.05
Any extrapyramidal related with adverse effect†	Zhou et al 201424	50	22	50	24	NS
Galactorrhoea (female)	Ren and Hu 201122	16	9	NR	0	NA
Gynecomastia (male)	Ren and Hu 201122	20	7	NR	0	NA
Akathisia	Ren and Hu 201122	36	0	36	1	NS
Any extrapyramidal related with adverse effect	Ren and Hu 201122	36	2	36	0	NS
Insomnia	Ren and Hu 201122	36	0	36	2	NS
Tremor	Chen et al 200920	40	4	40	4	NS
Dry mouth	Chen et al 200920	40	3	40	3	NS
ECG abnormality	Chen et al 200920	40	4	40	3	NS
Dizziness	Chen et al 200920	40	3	40	2	NS
Tachycardia	Chen et al 200920	40	6	40	8	NS
Anxiety	Chen et al 200920	40	5	40	4	NS
Constipation	Chen et al 200920	40	4	40	6	NS
Elevated liver enzymes	Chen et al 200920	40	6	40	5	NS
Hypersalivation	Chen et al 200920	40	6	40	8	NS
Hyperglycaemia	Chen et al 200920	40	2	40	3	NS

*Included amenorrhoea, oligomenorrhoea, galactorrhoea, etc.

†Included akathisia, tremor, oculogyric crisis, etc.

ADR, adverse drug reaction; NA, not applicable; NR, not reported; NS, not significant.