Skip to main content
. 2019 Oct 13;5(2):e001057. doi: 10.1136/rmdopen-2019-001057

Table 3.

Patient-level sum scores and inter-reader reliability of the four lesion types in the CANDEN MRI spine scoring system

Variable Baseline Week 52 Change
Score Single-measure ICC Average-measure ICC Score Single-measure ICC Average-measure ICC Score Single-measure ICC Average-measure ICC Wilcoxon test, p value
CANDEN MRI spine inflammation score, range 0–614 13.2 (5; 0–132) 0.91 (0.88–0.92) 0.95 (0.94–0.96) 2.4 (1; 0–19) 0.77 (0.67–0.86) 0.87 (0.81–0.92) −10.8 (−3; −113 to 1) 0.88 (0.86–0.92) 0.94 (0.93–0.96) <0.001
 Vertebral body corner inflammation subscore, range 0–254 8.0 (3; 0–89) 0.93 (0.91–0.95) 0.97 (0.95–0.97) 1.6 (0; 0–14) 0.84 (0.70–0.87) 0.91 (0.82–0.93) −6.4 (−2; −75 to 1) 0.90 (0.87–0.94) 0.95 (0.93–0.97) <0.001
 Spondylodiscitis subscore, range 0–162 1.8 (0; 0–25) 0.84 (0.74–0.91) 0.91 (0.85–0.95) 0.4 (0; 0–9) 0.66 (0.58–0.69) 0.80 (0.74–0.82) −1.3 (0; −22 to 0) 0.82 (0.79–0.89) 0.90 (0.88–0.94) 0.003
 Facet joint inflammation subscore, range 0–46 1.0 (0; 0–13) 0.78 (0.73–0.80) 0.88 (0.84–0.96) 0.2 (0; 0–2) 0.50 (0.23–0.64) 0.66 (0.37–0.78) −0.8 (0; −13 to 2) 0.79 (0.75–0.89) 0.88 (0.85–0.94) 0.001
 Posterolateral elements inflammation subscore, range 0–152 2.4 (0; 0–19) 0.55 (0.45–0.71) 0.71 (0.62–0.83) 0.2 (0; 0–2) 0.21 (0.16–0.32) 0.34 (0.28–0.48) −2.2 (0; −18 to 1) 0.55 (0.44–0.70) 0.71 (0.61–0.83) <0.001
CANDEN MRI spine fat score, range 0–510 6.8 (2; 0–49) 0.79 (0.75–0.86) 0.89 (0.86–0.92) 8.3 (4; 0–57) 0.79 (0.71–0.85) 0.88 (0.83–0.92) 1.5 (0; −4 to 11) 0.59 (0.46–0.73) 0.74 (0.63–0.85) <0.001
CANDEN MRI spine bone erosion score, range 0–208 0.3 (0; 0–2) 0.38 (0.32–0.52) 0.55 (0.48–0.68) 0.2 (0; 0–2) 0.32 (0.22–0.58) 0.49 (0.36–0.73) −0.1 (0; −1 to 0) 0.01 (−0.08 to 0.29) 0.01 (−0.17 to 0.45) 0.444
CANDEN MRI spine new bone formation score, range 0–460 3.1 (1; 0–24) 0.39 (0.27–0.49) 0.56 (0.42–0.65) 3.4 (1; 0–27) 0.38 (0.23–0.56) 0.55 (0.38–0.71) 0.2 (0; −1 to 3) 0.00 (0.00–0.00) 0.00 (0.00–0.00) 0.047

Scores are reported as mean (median; range) using the average score of all readers. ICCs are reported as the median (IQR) of 21 pairwise combinations of readers. Wilcoxon test for change between baseline and week 52.

CANDEN, Canada-Denmark; ICC, intraclass correlation coefficient.