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. 2019 Oct 15;6(2):e001108. doi: 10.1136/openhrt-2019-001108

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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The figure shows possible actions for interleukin-6 (IL-6) and targets for the anti-IL-6 antagonist, tocilizumab in the atherothrombotic process. Tocilizumab could (1) reduce initiation and progression of the atherosclerotic process, (2) stabilise atherosclerotic plaques, (3) inhibit initiation and propagation of the thrombus, (4) reduce ischaemia/reperfusion (I/R) injury, (5) inhibit the maladaptive left ventricular remodelling process and (6) prevent development of symptomatic heart failure. However, tocilizumab could potentially also attenuate infarct healing.