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. Author manuscript; available in PMC: 2020 Oct 28.
Published in final edited form as: Angew Chem Int Ed Engl. 2019 Sep 9;58(44):15904–15909. doi: 10.1002/anie.201908713

Table 1.

Determined Kd and IC50 values of selected cyclic peptides and their linear counterparts when binding to their protein targets.

Ligand Sequence[a] Protein target Kd (μM) IC50 (μM)
CycTev1 CWRDYLIX TEV protease 8.2 ± 0.8
LinTev1 CWRDYLIK TEV protease 50 ± 5
CycTev2 CQWFSHRX TEV protease 6.9 ± 0.9
LinTev2 CQWFSHRK TEV protease 39 ± 5
CycH8a CQSLWMNX HDAC8 7.1 ± 0.7 9.7 ± 0.7
LinH8a CQSLWMNK HDAC8 >50
LinH8a’ CQSLWMNNIe HDAC8 31 ± 7
[a]

X denotes AcrK.