. 2019 Sep 30;32(10):2118–2124. doi: 10.1021/acs.chemrestox.9b00299

Table 1. MdA₅₈ Depurination Kinetics as a Function of Environment.

substrate	k_Hyd (×10^–6 s^–1)	t_1/2 (h)	rel. t_1/2^c
free DNA^b	8.0 ± 1.1	24.4 ± 3.3
WT^b	2.2 ± 0.1	86.7 ± 3.2	3.6 ± 0.1
H3 Del.^b	2.3 ± 0.5	84.7 ± 17.2	3.5 ± 0.9
H4 Del.^b	2.9 ± 0.1	67.3 ± 0.1	2.8 ± 0.4
H3, H4 Del.^a	3.1 ± 0.3	61.9 ± 6.8	2.5 ± 0.4

Data are the average ± std. dev. of three replicates.

Data are the average ± std. dev. of two experiments each consisting of three replicates.

Rel. t_1/2 = t_1/2(NCP)/t_1/2(free DNA).

Table 1. MdA58 Depurination Kinetics as a Function of Environment.