. 2019 Sep 30;32(10):2118–2124. doi: 10.1021/acs.chemrestox.9b00299

Table 2. MdA₅₉ Depurination Kinetics as a Function of Environment.

substrate^a	k_Hyd (×10^–6 s^–1)	t_1/2 (h)	rel. t_1/2^b
free DNA	20.4 ± 1.3	9.5 ± 0.6
WT	10.7 ± 0.3	18.0 ± 0.5	1.9 ± 0.1
H3 Del.	10.8 ± 1.2	18.0 ± 1.9	1.9 ± 0.2
H4 Del.	13.0 ± 0.8	14.8 ± 1.0	1.6 ± 0.1
H3, H4 Del.	13.4 ± 2.8	14.4 ± 2.4	1.5 ± 0.3

Data are the average ± std. dev. of three replicates.

Rel. t_1/2 = t_1/2(NCP)/t_1/2(free DNA).

Table 2. MdA59 Depurination Kinetics as a Function of Environment.