. 2019 Sep 30;32(10):2118–2124. doi: 10.1021/acs.chemrestox.9b00299

Table 3. MdA₂₃₄ Depurination Kinetics as a Function of Environment.

substrate^a	k_Hyd (×10^–6 s^–1)	t_1/2 (h)	rel. t_1/2^b
free DNA	8.5 ± 0.4	22.6 ± 1.1
WT	2.8 ± 0.2	68.7 ± 4.9	3.0 ± 0.3
H3 Del.	3.0 ± 0.7	66.2 ± 15.6	2.9 ± 0.7
H4 Del.	4.1 ± 0.2	47.5 ± 2.6	2.1 ± 0.2
H3, H4 Del.	3.8 ± 0.1	50.6 ± 1.3	2.2 ± 0.1

Data are the average ± std. dev. of three replicates.

Rel. t_1/2 = t_1/2(NCP)/t_1/2(free DNA).

Table 3. MdA234 Depurination Kinetics as a Function of Environment.