. 2019 Sep 30;32(10):2118–2124. doi: 10.1021/acs.chemrestox.9b00299

Table 4. MdA₂₃₅ Depurination Kinetics as a Function of Environment.

substrate^a	k_Hyd (×10^–6 s^–1)	t_1/2 (h)	rel. t_1/2^b
free DNA	10.7 ± 2.6	18.8 ± 4.9
WT	3.0 ± 0.1	53.9 ± 2.5	2.9 ± 0.8
H3 Del.	4.8 ± 0.8	41.0 ± 7.0	2.2 ± 0.7
H4 Del.	6.2 ± 0.4	31.1 ± 2.1	1.6 ± 0.4
H3, H4 Del.	6.5 ± 1.1	29.1 ± 5.1	1.5 ± 0.5

Data are the average ± std. dev. of three replicates.

Rel. t_1/2 = t_1/2(NCP)/t_1/2(free DNA).

Table 4. MdA235 Depurination Kinetics as a Function of Environment.