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. Author manuscript; available in PMC: 2020 May 11.
Published in final edited form as: J Pharmacol Toxicol Methods. 2019 May 11;99:106580. doi: 10.1016/j.vascn.2019.106580

Fig. 3.

Fig. 3.

Head-out plethysmography chamber results. Respiratory rate (A), tidal volume (B), and minute volume (C) in rats dosed orally with 200, 500 or 750 mg/kg DSM421. Mean ± S.E.M. (n = 4–8 animals/dosing group, except at the 4 and 5 hours post-dosing time points due to severe behavioral signs that resulted in removal of some of the animals from the testing chambers prior to planned study completion). *P<0.05 for 750 mg/kg versus vehicle.