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. Author manuscript; available in PMC: 2020 May 11.
Published in final edited form as: J Pharmacol Toxicol Methods. 2019 May 11;99:106580. doi: 10.1016/j.vascn.2019.106580

Fig. 4.

Fig. 4.

Blood levels of ACTH (A), aldosterone (B) and corticosterone (C) in rats approximately 5 hours after oral dosing with 200, 500 or 750 mg/kg DSM421. Immediately prior to blood sampling, the rats had either been tested in whole-body or head-out plethysmography chambers (see Figs. 2 and 3). Mean ± S.E.M. (n = 4–8 animals/dosing group, but number of samples/group reduced for the 750 mg/kg dosing group in the head-out plethysmography study due to euthanasia in extremis of 2 of the 4 animals prior to planned study completion). *P<0.05 for whole-body versus head-out data matched to dose.