Table 2. The association results of seven SNPs on 8q24.22.
| SNP | Allele/ Genotype |
Discovery (1,442 vs. 1,468) | Replication (8,315 vs. 9,158) | Combined (9,757 vs. 10,726) | Sample pairs | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chr. Position Gene region | Cases, N (%) | Control, N (%) | OR (95% CI) | P | Case, N (%) | Control, N (%) | OR (95% CI) | P | Cases, N (%) | Control, N (%) | OR (95% CI) | P | ||||
| rs2703004 | A | 2,107 (73.1) | 2,230 (76.0) | 1.00 (ref) | 3,159 (72.2) | 3,161 (74.3) | 1.00 (ref) | 5,266 (72.6) | 5,391 (75.0) | 1.00 (ref) | 8,186 | |||||
| 134084800 | G | 777 (26.9) | 706 (24.0) | 1.17 (1.04–1.31) | 0.0108 | 1,215 (27.8) | 1,091 (25.7) | 1.11 (1.01–1.23) | 0.0253 | 1,992 (27.4) | 1,797 (25.0) | 1.14 (1.05–1.22) | 0.0009 | |||
| TG | AA | 764 (53.0) | 846 (57.6) | 1.00 (ref) | 1,138 (52) | 1,167 (54.9) | 1.00 (ref) | 1,902 (52.4) | 2,013 (56.0) | 1.00 (ref) | ||||||
| Intron41 | AG | 579 (40.2) | 538 (36.6) | 1.19 (1.02–1.39) | 883 (40.4) | 827 (38.9) | 1.09 (0.97–1.24) | 1,462 (40.3) | 1,365 (38.0) | 1.13 (1.25–1.07) | ||||||
| GG | 99 (6.9) | 84 (5.7) | 1.31 (0.96–1.77) | 0.0355 | 166 (7.6) | 132 (6.2) | 1.29 (1.01–1.64) | 0.0737 | 265 (7.3) | 216 (6.0) | 1.3 (1.03–1.57) | 0.0035 | ||||
| rs4301434 | A | 2,102 (72.9) | 2,227 (75.9) | 1.00 (ref) | 11,531 (72.6) | 12,565 (74.8) | 1.00 (ref) | 13,633 (72.7) | 14,792 (75.0) | 1.00 (ref) | 8,077 | |||||
| 134087450 | G | 782 (27.1) | 709 (24.1) | 1.17 (1.04–1.32) | 0.0092 | 4,345 (27.4) | 4,231 (25.2) | 1.12 (1.07–1.18) | 7.52E-06 | 5,127 (27.3) | 4,940 (25.0) | 1.13 (1.08–1.18) | 3.12E-07 | |||
| TG | AA | 760 (52.7) | 845 (57.6) | 1.00 (ref) | 4,198 (52.9) | 4,678 (55.7) | 1.00 (ref) | 4,958 (52.9) | 5,523 (56.0) | 1.00 (ref) | ||||||
| Intron41 | AG | 582 (40.4) | 537 (36.6) | 1.21 (1.03–1.4) | 3,135 (39.5) | 3,209 (38.2) | 1.09 (1.02–1.16) | 3,717 (39.6) | 3,746 (38.0) | 1.11 (1.17–1.17) | ||||||
| GG | 100 (6.9) | 86 (5.9) | 1.29 (0.95–1.75) | 0.0283 | 605 (7.6) | 511 (6.1) | 1.32 (1.16–1.49) | 1.84E-05 | 705 (7.5) | 597 (6.1) | 1.32 (1.04–1.48) | 1.20E-06 | ||||
| rs2294025 | G | 2,253 (78.1) | 2,404 (81.9) | 1.00 (ref) | 13,037 (78.4) | 14,538 (80.6) | 1.00 (ref) | 15,290 (78.4) | 16,942 (80.8) | 1.00 (ref) | 4,068 | |||||
| 134145512 | A | 631 (21.9) | 532 (18.1) | 1.27 (1.11–1.44) | 0.0003 | 3,593 (21.6) | 3,498 (19.4) | 1.15 (1.09–1.21) | 3.59E-07 | 4,224 (21.6) | 4,030 (19.2) | 1.16 (1.11–1.22) | 1.52E-09 | |||
| TG | GG | 870 (60.3) | 985 (67.1) | 1.00 (ref) | 5,124 (61.6) | 5,853 (64.9) | 1.00 (ref) | 5,994 (61.4) | 6,838 (65.2) | 1.00 (ref) | ||||||
| Intron46 | GA | 513 (35.6) | 434 (29.6) | 1.34 (1.14–1.57) | 2,789 (33.5) | 2,832 (31.4) | 1.12 (1.05–1.2) | 3,302 (33.8) | 3,266 (31.1) | 1.15 (1.12–1.2) | ||||||
| AA | 59 (4.1) | 49 (3.3) | 1.36 (0.92–2.01) | 0.0007 | 402 (4.8) | 333 (3.7) | 1.38 (1.19–1.6) | 1.55E-06 | 461 (4.7) | 382 (3.6) | 1.38 (1.09–1.58) | 9.67E-09 | ||||
| rs4736437 | T | 2,233 (77.4) | 2,379 (81.0) | 1.00 (ref) | 12,805 (77.2) | 14,548 (79.4) | 1.00 (ref) | 15,038 (77.3) | 16,927 (79.6) | 1.00 (ref) | 4,529 | |||||
| 134185668 | G | 651 (22.6) | 557 (19.0) | 1.25 (1.10–1.41) | 0.0006 | 3,777 (22.8) | 3,768 (20.6) | 1.14 (1.08–1.20) | 6.24E-07 | 4,428 (22.7) | 4,325 (20.4) | 1.15 (1.10–1.21) | 3.53E–09 | |||
| WISP1/SLA | TT | 856 (59.4) | 958 (65.3) | 1.00 (ref) | 4,959 (59.8) | 5,778 (63.1) | 1.00 (ref) | 5,815 (59.7) | 6,736 (63.4) | 1.00 (ref) | ||||||
| Intergenic | TG | 521 (36.1) | 463 (31.5) | 1.26 (1.08–1.47) | 2,887 (34.8) | 2,992 (32.7) | 1.12 (1.05–1.2) | 3,408 (35) | 3,455 (32.5) | 1.14 (1.21–1.19) | ||||||
| GG | 65 (4.5) | 47 (3.2) | 1.55 (1.05–2.28) | 0.0027 | 445 (5.4) | 388 (4.2) | 1.34 (1.16–1.54) | 3.32E-06 | 510 (5.2) | 435 (4.1) | 1.36 (1.08–1.55) | 2.84E-08 | ||||
| rs10956695 | A | 2,275 (78.9) | 2,414 (82.3) | 1.00 (ref) | 12,611 (79.2) | 13,501 (80.8) | 1.00 (ref) | 14,886 (79.2) | 15,915 (81.0) | 1.00 (ref) | 5,239 | |||||
| 134189138 | G | 609 (21.1) | 520 (17.7) | 1.24 (1.09–1.42) | 0.0009 | 3,303 (20.8) | 3,203 (19.2) | 1.10 (1.05–1.17) | 0.0004 | 3,912 (20.8) | 3,723 (19.0) | 1.12 (1.07–1.18) | 5.52E–06 | |||
| WISP1/SLA | AA | 892 (61.9) | 988 (67.3) | 1.00 (ref) | 5,015 (63.0) | 5,468 (65.5) | 1.00 (ref) | 5,907 (62.8) | 6,456 (65.8) | 1.00 (ref) | ||||||
| Intergenic | AG | 491 (34) | 438 (29.9) | 1.24 (1.06–1.45) | 2,581 (32.4) | 2,565 (30.7) | 1.1 (1.03–1.17) | 3,072 (32.7) | 3,003 (30.6) | 1.12 (1.19–1.1) | ||||||
| GG | 59 (4.1) | 41 (2.8) | 1.59 (1.06–2.4) | 0.0042 | 361 (4.5) | 319 (3.8) | 1.23 (1.06–1.44) | 0.0018 | 420 (4.5) | 360 (3.7) | 1.28 (1.05–1.47) | 3.35E-05 | ||||
| rs7005834 | A | 378 (13.1) | 490 (16.7) | 1.00 (ref) | 2,431 (14.6) | 2,803 (16.2) | 1.00 (ref) | 2,809 (14.4) | 3,293 (16.3) | 1.00 (ref) | 3,493 | |||||
| 134214204 | G | 2,506 (86.9) | 2,446 (83.3) | 1.33 (1.15–1.54) | 0.0001 | 14,179 (85.4) | 14,463 (83.8) | 1.13 (1.07–1.20) | 4.75E-05 | 16,685 (85.6) | 16,909 (83.7) | 1.16 (1.10–1.22) | 1.62E-07 | |||
| WISP1 | AA | 20 (1.4) | 45 (3.1) | 1.00 (ref) | 182 (2.2) | 224 (2.6) | 1.00 (ref) | 202 (2.1) | 269 (2.7) | 1.00 (ref) | ||||||
| Intron1 | AG | 338 (23.4) | 400 (27.2) | 1.9 (1.61–2.25) | 2,067 (24.9) | 2,355 (27.3) | 1.08 (0.88–1.33) | 2,405 (24.7) | 2,755 (27.3) | 1.16 (1.41–1.12) | ||||||
| GG | 1,084 (75.2) | 1,023 (69.7) | 2.38 (1.4–4.07) | 0.0003 | 6,056 (72.9) | 6,054 (70.1) | 1.23 (1.01–1.5) | 0.0002 | 7,140 (73.3) | 7,077 (70.1) | 1.34 (0.96–1.62) | 1.21E-06 | ||||
| rs4330674 | A | 344 (11.9) | 427 (14.5) | 1.00 (ref) | 609 (13.9) | 623 (14.7) | 1.00 (ref) | 953 (13.1) | 1050 (14.6) | 1.00 (ref) | 6,059 | |||||
| 134221502 | G | 2,540 (88.1) | 2,509 (85.5) | 1.26 (1.08–1.46) | 0.0031 | 3,763 (86.1) | 3,629 (85.3) | 1.06 (0.94–1.20) | 0.3406 | 6,303 (86.9) | 6,138 (85.4) | 1.13 (1.03–1.24) | 0.0098 | |||
| WISP1 | AA | 16 (1.1) | 31 (2.1) | 1.00 (ref) | 44 (2.0) | 50 (2.4) | 1.00 (ref) | 60 (1.7) | 81 (2.3) | 1.00 (ref) | ||||||
| Intron1 | AG | 312 (21.6) | 365 (24.9) | 1.66 (1.39–1.97) | 521 (23.8) | 523 (24.6) | 1.13 (0.74–1.73) | 833 (23.0) | 888 (24.7) | 1.27 (1.79–1) | ||||||
| GG | 1114 (77.3) | 1,072 (73.0) | 2.01 (1.09–3.7) | 0.0086 | 1,621 (74.2) | 1,553 (73.0) | 1.19 (0.79–1.79) | 0.6038 | 2,735 (75.4) | 2,625 (73.0) | 1.41 (0.9–1.97) | 0.0305 | ||||