Figure 4.

MDP transported by PepT1 contributes to activation of macrophages and antigen presentation of DCs. (A) The expression levels of serum IL-6, TNF-α, and NO in rat macrophages were measured by ELISA. *P<0.05, **P<0.01 versus MDP-Blank; ^##P<0.01 versus MDP-Blank. (B) The expression levels of CD80 and CD86 in rat DCs were measured by flow cytometry. (C) The antigen presentation of rat DCs were measured by flow cytometry. MDP, muramyl dipeptide; PepT1, peptide transporter; DC, dendritic cell; NO, nitric oxide.