FIG 2.
Virus cross-reactivity and epitopes targeted by MAbs induced by Flublok or Flucelvax immunization. Cross-reactivity to influenza group 1 (A/California/07/2009 H1N1 virus), group 2 (A/Switzerland/9715293/2013 H3N2 virus or A/South Australia/55/2014), and B strain (B/Phuket/3073/2013 virus or B/Utah/9/2014) as tested by ELISA. Assays were performed in duplicate three times for each antibody. ELISA binding affinities represented by KD (M) were plotted as a heatmap. Flublok-induced MAbs (n = 42) are compared to Flucelvax-induced MAbs (n = 38). MAbs were named based on the study name (150055), the subject identifier (032, for example) and the individual clone’s name. KD (M) values can also be found in Table S1 in the supplemental material.