FIG 2.

SNP composition of the two haplotype blocks observed in HVTN 505 participants. One of the haplotype blocks was comprised of five FCGR2C SNPs, and the other haplotype block was comprised of three FCGR3B SNPs. (A) Linkage disequilibrium measurements (D′) between the 8 SNP genotypes. (B) Correlation (r²) between the 8 SNP genotypes. (C) Haplotypes and frequencies within FCGR2C and FCGR3B haplotype blocks. Shown in each haplotype block are the haplotypes with a frequency of ≥1%. The haplotype designated with an asterisk in each haplotype block contains all minor alleles from the composite FcγR SNPs. Lines connecting haplotypes across haplotype blocks indicate the frequency of haplotype linkage, where line width represents frequency magnitude (thin lines for a frequency of ≥1% and thick lines for a frequency of ≥10%). Plots were generated using Haploview.