Comparison 7. Vitamin D + calcium versus placebo or no treatment.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Fracture	2	141	Risk Ratio (M‐H, Random, 95% CI)	0.14 [0.01, 2.90]
2 Acute graft rejection	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
3 Death	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
3.1 All causes	1		Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
4 Musculoskeletal disorders	2		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
4.1 Bone pain	1		Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
4.2 Avascular bone necrosis	1		Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
5 Bone mineral density [g calcium/cm2]	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
5.1 Vertebral	1		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
5.2 Femoral neck	1		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
6 Presence of low bone turnover on bone histomorphometry	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
7 Serum parathyroid hormone	2	188	Mean Difference (IV, Random, 95% CI)	‐0.32 [‐2.94, 2.31]
8 Graft loss	2	141	Risk Ratio (M‐H, Random, 95% CI)	2.38 [0.26, 22.12]
9 Serum creatinine	3	218	Mean Difference (IV, Random, 95% CI)	10.24 [‐0.05, 20.53]
10 eGFR [mL/min/1.73 m2]	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
11 Gastro‐oesophageal disorder	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
12 Hypercalcaemia	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected