Fan 2000.

Methods	Study design: parallel‐group, placebo‐controlled RCT Duration of study: not reported Duration of follow‐up: 48 months
Participants	Country: UK Setting: single centre Inclusion criteria: adult male cadaveric kidney transplant recipients Number: treatment group (14); control group (12) Mean age, range (years): treatment group (53, 23 to 66); control group (50, 23 to 74) Sex (M/F): all male Exclusion criteria: not reported
Interventions	Treatment group Parenteral pamidronate: 0.5 mg/kg in saline preoperatively and 1 month postoperatively Control group Placebo: parenteral saline
Outcomes	Serum calcium, phosphate BMD by DEXA at L2‐L4 and femoral neck
Notes	Funding source: not reported Trial registration: not applicable as published before end of 2005
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information to permit judgement
Allocation concealment (selection bias)	High risk	Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not reported in sufficient detail. Intervention and comparison were different and not described as identical.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	1 patient in the treatment group did not complete study (3rd transplant)
Selective reporting (reporting bias)	High risk	Patient‐centred outcomes including adverse events were not reported systematically
Other bias	Low risk	No additional threats to validity identified.