Nayak 2007.

Methods	Study design: open‐label, parallel RCT Duration of study: not reported Duration of follow‐up: 6 months
Participants	Country: India Setting: single centre Inclusion criteria: kidney transplant recipients Number: treatment group (27); control group (23) Mean age ± SD (years): not reported Sex (M/F): not reported Exclusion criteria: long‐term steroids prior to onset of kidney failure
Interventions	Treatment group Alendronate (oral)L 35 mg/week Control group No treatment Co‐interventions Calcium (oral): 1000 mg/d Vitamin D supplementation
Outcomes	Change in BMD at lumbar spine and femoral neck at 6 months
Notes	Funding source: not reported Trial registration: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information to permit judgement
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	High risk	Not described. Unlikely to be blinded due to differences between intervention and control (no therapy)
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Not reported in sufficient detail to per from adjudication
Selective reporting (reporting bias)	High risk	Patient important outcomes such as death and graft survival not captured and reported systematically
Other bias	Unclear risk	Insufficient information to permit judgement