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. 2019 Oct 22;2019(10):CD005015. doi: 10.1002/14651858.CD005015.pub4

Perez 2010.

Methods
  • Study design: active comparator, open‐label, parallel RCT

  • Duration of study: not reported

  • Duration of follow‐up: 12 months

Participants
  • Country: Spain

  • Setting: single centre

  • Inclusion criteria: kidney transplant recipients with stable kidney function

  • Number: treatment group (31); control group (21)

  • Mean age, range (years): treatment group (60, 53 to 65); control group (55, 42 to 61)

  • Sex (M/F): treatment group (26/5); control group (17/4)

  • Exclusion criteria: not reported

Interventions Treatment group
  • Paricalcitol (oral): 1µg/d


Control group
  • No treatment


Co‐interventions
  • Not reported

Outcomes
  • Change in BMD at lumbar spine and femoral neck

  • Change in PTH, serum calcium, phosphate, alkaline phosphatase

  • Kidney function (eGFR and SCr)

Notes
  • Funding source: not reported

  • Trial registration: not reported

Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Insufficient information to permit judgement
Allocation concealment (selection bias) Unclear risk Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Not blinded. Patients allocated to oral treatment or no treatment
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Insufficient information to permit judgement
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk Insufficient information to permit judgement
Selective reporting (reporting bias) High risk Patient important outcomes not captured or reported systematically
Other bias Low risk No additional threats to validity identified